研究業績

【論文】

Insight into Isoprenoid Biosynthesis by Functional Analysis of Isoprenyl Diphosphate Synthases from Mycobacterium vanbaalenii and Mycobacterium tuberculosis. Abe T, Ozaki S, Ueda D, Sato T Chembiochem : a European journal of chemical biologyin press

Molecular Basis for Sesterterpene (C25) Diversity Produced by Plant Terpene Synthases. Qingwen Chen, Jianxu Li, Zhixi Liu, Takaaki Mitsuhashi, Yuting Zhang, Haili Liu, Yihua Ma, Juan He, Tetsuro Shinada, Tsutomu Sato, Yong Wang, Hongwei Liu, Ikuro Abe, Peng Zhang,Guodong Wang.Plant communication in press


Characterization of Class IB terpene synthase: the first crystal structure bound with substrate surrogate. Stepanova Rafaella, Inagi Hayato, Sugawara Kei, Asada Kazuya, Nishi Tomoyuki, Ueda Daijiro, Yasuno Yoko, Shinada Tetsuro, Miki Kunio, Fujihashi Masahiro, Sato Tsutomu. ACS Chem. biol. in press


Adduct Formation of Delamanid with NAD in Mycobacteria.Mikayo Hayashi, Akihito Nishiyama, Ryuki Kitamoto, Yoshitaka Tateishi, Mayuko Osada-Oka, Yukiko Nishiuchi, Shaban A. Kaboso, Xiuhao Chen, Mamoru Fujiwara, Yusuke Inoue, Yoshikazu Kawano, Masanori Kawasaki, Tohru Abe, Tsutomu Sato, Kentaro Kaneko, Kimiko Itoh, Sohkichi Matsumoto, Makoto Matsumoto. Antimicrobial Agents and Chemotherapy, 64(5) 1-12 2020


Japanese Rice Wine can reduce psychophysical stress-induced depression-like behaviors and Fos expression in the trigeminal subnucleus caudalis evoked by masseter muscle injury in the rats.
Nakatani Y, Kakihara Y, Shimizu S, Kurose M, Sato T, Kaneoke M, Saeki M, Takagi R, Yamamura K, Okamoto K
Bioscience, Biotechnology, and Biochemistry 83(1) 155- 165 2019


An Aromatic Farnesyltransferase Functions in Biosynthesis of the Anti-HIV Meroterpenoid Daurichromenic Acid.
Saeki H, Hara R, Takahashi H, Iijima M, Munakata R, Kenmoku H, Fuku K, Sekihara A, Yasuno Y, Shinada T, Ueda D, Nishi T, Sato T, Asakawa Y, Kurosaki F, Yazaki K, Taura F
Plant physiology 178(2) 535 - 551 2018


A Non-Enzymatic Pathway with Superoxide in Intracellular Terpenoid Synthesis.
Ueda D, Matsugane S, Okamoto W, Hashimoto M, Sato T
Angewandte Chemie (International ed. in English) 57(32) 10347 - 10351 2018


Crystal structure and functional analysis of large-terpene synthases belonging to a newly found subclass.
Fujihashi M, Sato T, Tanaka Y, Yamamoto D, Nishi T, Ueda D, Murakami M, Yasuno Y, Sekihara A, Fuku K, Shinada T, Miki K
Chemical science 9(15) 3754 - 3758 2018


Bioinspired synthesis of pentacyclic onocerane triterpenoids.
Bartels F, Hong YJ, Ueda D, Weber M, Sato T, Tantillo DJ, Christmann M
Chemical science 8(12) 8285 - 8290 2017


Analysis of the Catalytic Mechanism of Bifunctional Triterpene/Sesquarterpene Cyclase: Tyr167 Functions To Terminate Cyclization of Squalene at the Bicyclic Step.
Tenkovskaia L, Murakami M, Okuno K, Ueda D, Sato T
Chembiochem : a European journal of chemical biology 18(19) 1910 - 1913 2017


Biosynthesis of Sesterterpenes, Head-to-Tail Triterpenes, and Sesquarterpenes in Bacillus clausii: Identification of Multifunctional Enzymes and Analysis of Isoprenoid Metabolites.
Ueda D, Yamaga H, Murakami M, Totsuka Y, Shinada T, Sato T
Chembiochem : a European journal of chemical biology 16(9) 1371 - 1377 2015


Cyclization of squalene from both termini: identification of an onoceroid synthase and enzymatic synthesis of ambrein.
Ueda D, Hoshino T, Sato T
Journal of the American Chemical Society 135(49) 18335 - 18338 2013


Enzymatic syntheses of unnatural head-to-tail pentacyclic triterpenes by tetraprenyl-beta-curcumene cyclase
Okamoto Wataru, Sato Tsutomu
TETRAHEDRON LETTERS 54(49) 6747 - 6750 2013


Identification of novel sesterterpene/triterpene synthase from Bacillus clausii.
Sato T, Yamaga H, Kashima S, Murata Y, Shinada T, Nakano C, Hoshino T
Chembiochem : a European journal of chemical biology 14(7) 822 - 825 2013


Insight into the pathway for biosynthesis of sesquarterpenes in nonpathogenic Mycobacterium species: identification of heptaprenylcycli-14E,18E-diene
Sato Tsutomu, Ono Eri, Nakajima Mami, Nakano Chiaki, Hoshino Tsutomu
TETRAHEDRON LETTERS 53(20) 2522 - 2524 2012


Bifunctional triterpene/sesquarterpene cyclase: tetraprenyl-β-curcumene cyclase is also squalene cyclase in Bacillus megaterium.
Sato T, Hoshino H, Yoshida S, Nakajima M, Hoshino T
Journal of the American Chemical Society 133(44) 17540 - 17543 2011


Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-β-curcumene synthase and a tetraprenyl-β-curcumene cyclase: identification of a new terpene cyclase.
Sato T, Yoshida S, Hoshino H, Tanno M, Nakajima M, Hoshino T
Journal of the American Chemical Society 133(25) 9734 - 9737 2011


Insight into C35 terpene biosyntheses by nonpathogenic Mycobacterium Species: functional analyses of three Z-prenyltransferases and identification of dehydroheptaprenylcyclines.
Sato T, Takizawa K, Orito Y, Kudo H, Hoshino T
Chembiochem : a European journal of chemical biology 11(13) 1874 - 1881 2010


Novel compounds of octahydroheptaprenyl mycolic acyl ester and monocyclic C35-terpene, heptaprenylcycline B, from non-pathogenic mycobacteriumspecies.
Sato T, Takagi R, Orito Y, Ono E, Hoshino T
Bioscience, biotechnology, and biochemistry 74(1) 147 - 151 2010

Biosynthesis of a novel cyclic C35-terpene via the cyclisation of a Z-type C35-polyprenyl diphosphate obtained from a nonpathogenic Mycobacterium species.
Sato T, Kigawa A, Takagi R, Adachi T, Hoshino T
Organic & biomolecular chemistry 6(20) 3788 - 3794 2008

 

【総説・解説】

龍涎香に関する研究
上田大次郎, 佐藤努
季刊香料 (273) 53‐59 2017年3月20日

龍涎香に関する研究
上田 大次郎, 佐藤 努
香料 (273) 53 - 59 2017

龍涎香の主成分アンブレインの酵素合成
上田大次郎, 星野力, 佐藤努
Aroma Res 16(2) 142 - 143 2015

龍涎香の主成分アンブレインの酵素合成
上田大次郎, 星野力, 佐藤努
バイオサイエンスとインダストリー 72(5) 410 - 411 2014

Unique biosynthesis of sesquarterpenes (C35 terpenes).
Sato T
Bioscience, biotechnology, and biochemistry 77(6) 1155 - 1159 2013

ユニークなセスクアテルペン(C35テルペン)生合成経路 : 今までに類のない新型と二機能性テルペン環化酵素の同定
佐藤 努
化学と生物 50(9) 622 - 623 2012

 

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